DR FEDERICA AMATI: How Weight Loss Drugs Can Rewire Your Brain

Dr Federica Amati is the Head Nutritionist at ZOE and author of The Appetite Reset, https://amzn.eu/d/0iodLEof. She first came on the show back in 2024 and she completely blew my mind. Now she's back… And this time, she's tackling weight loss drugs. What started as a prescription treatment for diabetes has become a global cultural phenomenon, with millions now taking GLP-1s to lose weight. Dr Federica reveals that people can eat up to 40% less food while taking these drugs, causing significant changes to their bodies. She also explains how they can rewire our brains, as well as the short and long term effects of taking them. In this episode, she shares: - How weight loss drugs really affect our bodies and minds - The connection between GLP-1s and addiction - How ‘skinny jabs’ are changing our supermarket shelves - Why young women may face unique long-term risks from GLP-1s This is a fascinating conversation about medication that’s changing the way we think about our health, our bodies, and our relationship with food. Dr Federica Amati is Great Company. You can buy Dr Federica’s latest book, The Appetite Reset here: https://amzn.eu/d/0iodLEof If you enjoyed the show, you can also follow us: Instagram - https://www.instagram.com/greatcompanypodcast/ TikTok - https://www.tiktok.com/@greatcompanypodcast Jamie - https://www.instagram.com/jamielaing And if you've got thoughts, questions and comments, you can email us at: greatcompany@jampotproductions.co.uk Need a laptop for the kids or new headphones to survive the summer playlist on repeat? Back Market has you covered with professionally refurbished tech — phones, laptops, headphones, cameras and more — all backed by a 1-year warranty, 30-day returns, free shipping, and up to a 100-point inspection. Save up to 50% vs. buying new! Students & teachers: check the site for exclusive discounts. Get £20 off when you spend £250+ (until end of September) with code GREATCOMPANY20. Shop now at BackMarket.co.uk or on the Back Market app 00:00 Coming Up 01:32 Jamie’s intro 02:20 Dr Federica is back 03:50 How becoming a parent changes your brain 07:00 What are the ACES? 11:49 Are weight loss drugs a miracle drug? 22:34 The connection between peptides and weight loss drugs 28:00 “These medicines are not for humans” 32:13 GLP-1s vs addiction 37:15 How do weight loss drugs affect our bodies and brains 41:38 The danger of adverts targeting women 46:14 The number one reason quit weight loss drugs 53:19 Taking GLP-1s in your twenties 59:00 Dr Federica on changing weight loss drug usage 1:04:11 How skinny jabs are changing out supermarket shelves 1:13:00 6 rules to a healthy life 1:018:29 Final 8 questions THE CREDITS Producer: Magda Cassidy & Helen Burke Assistant Producer: Issy Weeks-Hankins Video: Josh Bennett Senior Social Media Manager: Laura Coughlan Audio: Rafi Amsili Geovannetti Shot on Sony Cinema Line cameras FX6, FX2 with Sony G-Master lenses 16-35GM, 24-70GM