Antibody Structure: The Immunoglobulin Fold and Antibody-Antigen Interactions

Dr. KP gives an overview of antibody structure, and takes a look at a human antibody bound to the SARS-CoV-2 spike protein. PDB IDs Available at rcsb.org: 1igt, 7k90 REFERENCES • Akkaya, M., Kwak, K. & Pierce, S.K. B cell memory: building two walls of protection against pathogens. Nat Rev Immunol 20, 229–238 (2020). https://doi.org/10.1038/s41577-019-0244-2 • Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. • Barnes, C.O., Jette, C.A., Abernathy, M.E. et al. SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature 588, 682–687 (2020). https://doi.org/10.1038/s41586-020-2852-1 • Chiu ML, Goulet DR, Teplyakov A, Gilliland GL. Antibody Structure and Function: The Basis for Engineering Therapeutics. Antibodies (Basel). 2019;8(4):55. Published 2019 Dec 3. doi:10.3390/antib8040055 • Lambert, J. M., & Berkenblit, A. (2018). Antibody–drug conjugates for cancer treatment. Annual review of medicine, 69, 191-207. • Nose M, Wigzell H. Biological significance of carbohydrate chains on monoclonal antibodies. Proc Natl Acad Sci U S A. 1983;80(21):6632-6636. doi:10.1073/pnas.80.21.6632 • Pan S, Manabe N, Yamaguchi Y. 3D Structures of IgA, IgM, and Components. Int J Mol Sci. 2021;22(23):12776. Published 2021 Nov 26. doi:10.3390/ijms222312776 • Vollmers, H. Peter, and Stephanie Brändlein. Natural antibodies and cancer. New biotechnology 25.5 (2009): 294-298.