Why High LDL Cholesterol Doesn’t Always Lead to Heart Disease

Why do some individuals with sky-high LDL cholesterol and ApoB appear resistant to heart disease, while others with lower LDL and ApoB do develop heart disease? In this video, we dive deep into one mechanism behind this paradox, exploring how cholesterol-containing particles enter the blood vessel walls and "seed" coronary plaques. We also discuss groundbreaking new data that shows a population with extremely high LDL cholesterol may actually be at lower risk for heart disease. This video challenges conventional beliefs and promotes data-driven insights over dogma. We’ll cover how LDL cholesterol, ApoB, and metabolic health play a role in cardiovascular risk and plaque formation while highlighting the importance of individual variability in heart disease risk. Big New Paper, please read and share: https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686 The Video: https://youtu.be/a_ROZPW9WrY Cholesterol Code Movie! Please sign up for newsletter: http://cholesterolcodemovie.com For a written breakdown, references and links, see the associated Stay Curious Metabolism Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/why-some-people-with-sky-high-ldl?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Chapters 0:00 – Heart Disease Beyond LDL Cholesterol 1:12 – High LDL and ApoB and Healthy?! 1:41 – What is “Transcytosis?” 4:05 – A big Assumption… 5:49 – My Life is on the Line 6:24 – Regulation of Transcytosis: LDL receptor 7:28 – Regulation of Transcytosis: SR-B1 8:38 – Regulation of Transcytosis: ALK1 9:32 – Summary of Mechanisms 10:48 – Conclusions and Call to Action #LDL #ApoB #heartdisease #cholesterol #LEM #LMHR #HDL #hearthealth #insulinresistance #metabolichealth #cholesterolcode #staycurious #cholesterolsupport #heartdiseaseprevention #metabolicsyndrome #cardiovascularhealth #cholesterolresearch #lipidmanagement #cardiovascularrisk #dietandhealth #lipidprofile #healthandwellness #lowcarbdiet #ketogeniclifestyle #healthyheart, #healthscience #heartdiseaseawareness #cholesterolmyths #metabolicallyhealthy #staycurious