College Football Week 1 Picks 2026: Upsets, Predictions & Games to Watch

College Football Week 1 predictions are here! I’m picking EVERY major Week 1 game of the 2026 college football season, including Clemson vs LSU, Boise State vs Oregon, Baylor vs Auburn, Wisconsin vs Notre Dame, Louisville vs Ole Miss and more. Who gets upset in Week 1? Which contenders start the 2026 season with a statement win? I’m breaking down my college football Week 1 picks and predictions from Friday through Labor Day Monday, with rapid-fire picks, upset alerts, featured matchups and analysis on the biggest games of the weekend. The biggest showdown on my board is Clemson vs LSU, but there are plenty of other games that could shake up the college football landscape. We’ll also get into Boise State vs Oregon, Baylor vs Auburn, Wisconsin vs Notre Dame, Louisville vs Ole Miss, SMU vs Florida State, Washington State vs Washington, Tulane vs Duke and more. I’ll give you my winner for each matchup, explain what I’m watching in the biggest games, and identify the teams I believe could surprise people in Week 1 of the 2026 college football season. Featured Week 1 matchups include: Clemson vs LSU Boise State vs Oregon Baylor vs Auburn Wisconsin vs Notre Dame Louisville vs Ole Miss SMU vs Florida State Washington State vs Washington Tulane vs Duke Tennessee State vs Georgia Who is YOUR biggest Week 1 upset pick? Drop your predictions in the comments and tell me where you think I got it wrong. If you love college football predictions, CFB rankings, College Football Playoff talk, game previews, film breakdowns, upset picks and college football analysis, subscribe and join us throughout the 2026 college football season. #CollegeFootball #CollegeFootballPredictions #CFB