Fructose & Human Clinical Trials | Kimber Stanhope | Episode 307

Controlled human feeding trials show added fructose raises liver fat, triglycerides, uric acid, and insulin resistance at real-world doses. All M&M content is available on Substack. Podcast, writing, weekly newsletter: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ http://tiny.cc/supportmm ] Personalized health consulting: work directly with Dr. Nick Jikomes: [ https://www.nickjikomes.com ] Nick Jikomes hosts Mind & Matter, a podcast on neuroscience, metabolism, and biology for an intelligent non-specialist audience. Subscribe and leave a comment with the topic you found most surprising. #Fructose #Glucose #HFCS #FattyLiver #MetabolicHealth #Nutrition #Science #Podcast Chapters: 00:00:00 Intro 00:03:27 Sugar Forms & HFCS Basics 00:06:02 Fruit Sugar vs Processed Food 00:13:16 HFCS 55 vs What Is on Shelves 00:20:21 Why Fructose vs Glucose Matters 00:23:55 Fructose & Liver First Pass 00:26:40 Triglycerides & Fatty Liver 00:34:34 Why Fructose Is Poorly Regulated 00:39:56 Uric Acid & Oxidative Stress 00:49:12 Dose & Real-World Sugar Intake 00:56:05 Clinical Feeding Trial Design 01:02:11 Epidemiology vs Feeding Trials 01:08:14 How Much Added Sugar Is Too Much 01:11:39 Sucrose vs HFCS Head to Head 01:17:48 Fiber, Whole Grains & Liver Load 01:23:32 Ongoing Clinical Research 01:26:33 Orange Juice vs Sucrose Trial 01:36:53 Sugar-Sweetened Drinks vs Milk 01:43:34 Practical Takeaways 01:51:02 Outro